Serum plant sterols and biliary cholesterol secretion in humans
نویسندگان
چکیده
منابع مشابه
Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine.
BACKGROUND Cholesterol metabolic studies are simplified in colectomized patients because of rapid intestinal passage and reduced bacterial action. OBJECTIVE Our objective was to study the effect on cholesterol and plant sterol metabolism of feeding a margarine containing stanol ester to 11 colectomized patients. DESIGN A margarine containing 2 g stanol was consumed for 7-18 d. Serum, biliar...
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We used lovastatin, a specific inhibitor of HMG-CoA reductase, to study the role of cholesterol synthesis in regulation of both bile acid synthesis, measured by release of 14CO2 from [26-14C]cholesterol, and biliary cholesterol secretion, measured by standard marked perfusion techniques, in humans. Six volunteers were studied in each of four periods: a) control; b) 6-10 hours after a single 40 ...
متن کاملDietary plant sterols and cholesterol metabolism.
Plant sterols, naturally occurring in foods of plant origin, reduce cholesterol absorption. Experimental studies show plant sterols to be an important part of the serum-cholesterol lowering effect of certain diets and dietary components. Epidemiological data show that individuals with higher intakes of plant sterols from their habitual diets have lower serum-cholesterol levels. To date, the rol...
متن کاملDisruption of cholesterol homeostasis by plant sterols.
The ABC transporters ABCG5 and ABCG8 limit absorption and promote excretion of dietary plant sterols. It is not known why plant sterols are so assiduously excluded from the body. Here we show that accumulation of plant sterols in mice lacking ABCG5 and ABCG8 (G5G8-/- mice) profoundly perturbs cholesterol homeostasis in the adrenal gland. The adrenal glands of the G5G8-/- mice were grossly abnor...
متن کاملPlant sterols beyond low-density lipoprotein-cholesterol.
Moderate hypercholesterolaemia still remains one of the commonest metabolic disorders in developed societies, largely due to the effect of an inappropriate diet with high intake of saturated and trans fatty acids. This form of hypercholesterolaemia is often accompanied by arterial hypertension which may increase the atherogenicity of even moderately increased concentrations of the LDL fraction....
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2002
ISSN: 0022-2275
DOI: 10.1194/jlr.m100438-jlr200